Synthetic Lethality of Cohesins with PARPs and Replication Fork Mediators

Synthetic lethality has been proposed as a way to leverage the genetic differences found in tumor cells to affect their selective killing. Cohesins, which tether sister chromatids together until anaphase onset, are mutated in a variety of tumor types. The elucidation of synthetic lethal interactions...

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Main Authors: McLellan, Jessica L., O'Neil, Nigel J., Barrett, Irene, Ferree, Elizabeth, van Pel, Derek M., Ushey, Kevin, Sipahimalani, Payal, Bryan, Jennifer, Rose, Ann M., Hieter, Philip
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3297586/
https://ncbi.nlm.nih.gov/pubmed/22412391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002574
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