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Synthetic Lethality of Cohesins with PARPs and Replication Fork Mediators
Synthetic lethality has been proposed as a way to leverage the genetic differences found in tumor cells to affect their selective killing. Cohesins, which tether sister chromatids together until anaphase onset, are mutated in a variety of tumor types. The elucidation of synthetic lethal interactions...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3297586/ https://ncbi.nlm.nih.gov/pubmed/22412391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002574 |
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