Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors

DNA sequence and epigenetic information embedded in chromatin must be faithfully duplicated and transmitted to daughter cells during cell division. However, how chromatin assembly and DNA replication are integrated remains unclear. We examined the contribution of the Tousled-like kinases 1 and 2 (TL...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Lee, Sung-Bau, Segura-Bayona, Sandra, Villamor-Payà, Marina, Saredi, Giulia, Todd, Matthew A. M., Attolini, Camille Stephan-Otto, Chang, Ting-Yu, Stracker, Travis H., Groth, Anja
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6082654/
https://ncbi.nlm.nih.gov/pubmed/30101194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aat4985
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