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Synthetic Lethality and Cancer: Cohesin and PARP at the Replication Fork
Cohesins are mutated in a significant number of tumors of various types making them an attractive target for chemotherapeutic intervention. However, cohesins have a spectrum of cellular roles including sister chromatid cohesion, transcription, replication, and repair. Which of these roles are centra...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3868440/ https://ncbi.nlm.nih.gov/pubmed/23333522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tig.2012.12.004 |
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