Cohesin mutations are synthetic lethal with stimulation of WNT signaling

Mutations in genes encoding subunits of the cohesin complex are common in several cancers, but may also expose druggable vulnerabilities. We generated isogenic MCF10A cell lines with deletion mutations of genes encoding cohesin subunits SMC3, RAD21, and STAG2 and screened for synthetic lethality wit...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Chin, Chue Vin, Antony, Jisha, Ketharnathan, Sarada, Labudina, Anastasia, Gimenez, Gregory, Parsons, Kate M, He, Jinshu, George, Amee J, Pallotta, Maria Michela, Musio, Antonio, Braithwaite, Antony, Guilford, Parry, Hannan, Ross D, Horsfield, Julia A
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2020
Gaiak:
Cancer Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7746233/
https://ncbi.nlm.nih.gov/pubmed/33284104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61405
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