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Structural Basis of HIV‑1 Inhibition by Nucleotide-Competing Reverse Transcriptase Inhibitor INDOPY‑1

HIV-1 reverse transcriptase (RT) is an essential enzyme, targeting half of approved anti-AIDS drugs. While nucleoside RT inhibitors (NRTIs) are DNA chain terminators, the nucleotide-competing RT inhibitor (NcRTI) INDOPY-1 blocks dNTP binding to RT. Lack of structural information hindered INDOPY-1 im...

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Bibliografische gegevens
Gepubliceerd in:J Med Chem
Hoofdauteurs: Ruiz, F. Xavier, Hoang, Anthony, Das, Kalyan, Arnold, Eddy
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7737671/
https://ncbi.nlm.nih.gov/pubmed/31603676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01289
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