Oxidative stress mediates thalidomide-induced pain by targeting peripheral TRPA1 and central TRPV4

BACKGROUND: The mechanism underlying the pain symptoms associated with chemotherapeutic-induced peripheral neuropathy (CIPN) is poorly understood. Transient receptor potential ankyrin 1 (TRPA1), TRP vanilloid 4 (TRPV4), TRPV1, and oxidative stress have been implicated in several rodent models of CIP...

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Vydáno v:BMC Biol
Hlavní autoři: De Logu, Francesco, Trevisan, Gabriela, Marone, Ilaria Maddalena, Coppi, Elisabetta, Padilha Dalenogare, Diéssica, Titiz, Mustafa, Marini, Matilde, Landini, Lorenzo, Souza Monteiro de Araujo, Daniel, Li Puma, Simone, Materazzi, Serena, De Siena, Gaetano, Geppetti, Pierangelo, Nassini, Romina
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7737339/
https://ncbi.nlm.nih.gov/pubmed/33317522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-020-00935-9
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