Discovery of Highly Selective and Potent HDAC3 Inhibitors Based on a 2-Substituted Benzamide Zinc Binding Group

[Image: see text] The selectivity of histone deacetylase inhibitors (HDACis) is greatly impacted by the zinc binding groups. In an effort to search for novel zinc binding groups, we applied a parallel medicinal chemistry (PMC) strategy to quickly synthesize substituted benzamide libraries. We discov...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Liu, Jian, Yu, Younong, Kelly, Joseph, Sha, Deyou, Alhassan, Abdul-Basit, Yu, Wensheng, Maletic, Milana M., Duffy, Joseph L., Klein, Daniel J., Holloway, M. Katharine, Carroll, Steve, Howell, Bonnie J., Barnard, Richard J. O., Wolkenberg, Scott, Kozlowski, Joseph A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2020
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734795/
https://ncbi.nlm.nih.gov/pubmed/33335670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00462
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