Synthesis of HDAC Inhibitor Libraries via Microscale Workflow

[Image: see text] An integrated workflow has been established that enables the synthesis, purification, and subsequent biological testing of compound libraries on a microgram scale. This approach utilizes mass directed preparative HPLC in conjunction with charged aerosol detection (CAD) to generate...

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Bibliografiske detaljer
Udgivet i:ACS Med Chem Lett
Main Authors: Dykstra, Kevin D., Streckfuss, Eric, Liu, Min, Liu, Jian, Yu, Younong, Wang, Ming, Kozlowski, Joseph A., Myers, Robert W., Buevich, Alexei V., Maletic, Milana M., Vachal, Petr, Krska, Shane W.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2021
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7957937/
https://ncbi.nlm.nih.gov/pubmed/33738059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00596
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