Improved Selective Class I HDAC and Novel Selective HDAC3 Inhibitors: Beyond Hydroxamic Acids and Benzamides

[Image: see text] The application of class I HDAC inhibitors as cancer therapies is well established, but more recently their development for nononcological indications has increased. We report here on the generation of improved class I selective human HDAC inhibitors based on an ethylketone zinc bi...

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Bibliografiske detaljer
Udgivet i:ACS Med Chem Lett
Main Authors: Bresciani, Alberto, Ontoria, Jesus M., Biancofiore, Ilaria, Cellucci, Antonella, Ciammaichella, Alina, Di Marco, Annalise, Ferrigno, Federica, Francone, Alessandra, Malancona, Savina, Monteagudo, Edith, Nizi, Emanuela, Pace, Paola, Ponzi, Simona, Rossetti, Ilaria, Veneziano, Maria, Summa, Vincenzo, Harper, Steven
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2018
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466521/
https://ncbi.nlm.nih.gov/pubmed/30996783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00517
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