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E3 Ubiquitin Ligase APC/C(Cdh1) Regulation of Phenylalanine Hydroxylase Stability and Function

Phenylketonuria (PKU) is an autosomal recessive metabolic disorder caused by the dysfunction of the enzyme phenylalanine hydroxylase (PAH). Alterations in the level of PAH leads to the toxic accumulation of phenylalanine in the blood and brain. Protein degradation mediated by ubiquitination is a pri...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Int J Mol Sci
Prif Awduron: Tyagi, Apoorvi, Sarodaya, Neha, Kaushal, Kamini, Chandrasekaran, Arun Pandian, Antao, Ainsley Mike, Suresh, Bharathi, Rhie, Byung Ho, Kim, Kye Seong, Ramakrishna, Suresh
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7729981/
https://ncbi.nlm.nih.gov/pubmed/33260674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21239076
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