E3 Ubiquitin Ligase APC/C(Cdh1) Regulation of Phenylalanine Hydroxylase Stability and Function

Phenylketonuria (PKU) is an autosomal recessive metabolic disorder caused by the dysfunction of the enzyme phenylalanine hydroxylase (PAH). Alterations in the level of PAH leads to the toxic accumulation of phenylalanine in the blood and brain. Protein degradation mediated by ubiquitination is a pri...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Tyagi, Apoorvi, Sarodaya, Neha, Kaushal, Kamini, Chandrasekaran, Arun Pandian, Antao, Ainsley Mike, Suresh, Bharathi, Rhie, Byung Ho, Kim, Kye Seong, Ramakrishna, Suresh
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7729981/
https://ncbi.nlm.nih.gov/pubmed/33260674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21239076
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