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E3 Ubiquitin Ligase APC/C(Cdh1) Negatively Regulates FAH Protein Stability by Promoting Its Polyubiquitination

Fumarylacetoacetate hydrolase (FAH) is the last enzyme in the degradation pathway of the amino acids tyrosine and phenylalanine in mammals that catalyzes the hydrolysis of 4-fumarylacetoacetate into acetoacetate and fumarate. Mutations of the FAH gene are associated with hereditary tyrosinemia type...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Kaushal, Kamini, Woo, Sang Hyeon, Tyagi, Apoorvi, Kim, Dong Ha, Suresh, Bharathi, Kim, Kye-Seong, Ramakrishna, Suresh
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7699203/
https://ncbi.nlm.nih.gov/pubmed/33218190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21228719
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