E3 Ubiquitin Ligase APC/C(Cdh1) Negatively Regulates FAH Protein Stability by Promoting Its Polyubiquitination

Fumarylacetoacetate hydrolase (FAH) is the last enzyme in the degradation pathway of the amino acids tyrosine and phenylalanine in mammals that catalyzes the hydrolysis of 4-fumarylacetoacetate into acetoacetate and fumarate. Mutations of the FAH gene are associated with hereditary tyrosinemia type...

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Bibliografiska uppgifter
I publikationen:Int J Mol Sci
Huvudupphovsmän: Kaushal, Kamini, Woo, Sang Hyeon, Tyagi, Apoorvi, Kim, Dong Ha, Suresh, Bharathi, Kim, Kye-Seong, Ramakrishna, Suresh
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7699203/
https://ncbi.nlm.nih.gov/pubmed/33218190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21228719
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