E3 Ubiquitin Ligase APC/C<sup>Cdh1</sup> Negatively Regulates FAH Protein Stability by Promoting Its Polyubiquitination

Fumarylacetoacetate hydrolase (FAH) is the last enzyme in the degradation pathway of the amino acids tyrosine and phenylalanine in mammals that catalyzes the hydrolysis of 4-fumarylacetoacetate into acetoacetate and fumarate. Mutations of the <i>FAH</i> gene are associated with hereditar...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kamini Kaushal, Sang Hyeon Woo, Apoorvi Tyagi, Dong Ha Kim, Bharathi Suresh, Kye-Seong Kim, Suresh Ramakrishna
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: MDPI AG 2020-11-01
Saila:International Journal of Molecular Sciences
Gaiak:
CRISPR/Cas9 knockout
in silico analysis
liver cancer
post-translational modifications
ubiquitin-proteasome system
Sarrera elektronikoa:https://www.mdpi.com/1422-0067/21/22/8719
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