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E3 Ubiquitin Ligase APC/C(Cdh1) Negatively Regulates FAH Protein Stability by Promoting Its Polyubiquitination

Fumarylacetoacetate hydrolase (FAH) is the last enzyme in the degradation pathway of the amino acids tyrosine and phenylalanine in mammals that catalyzes the hydrolysis of 4-fumarylacetoacetate into acetoacetate and fumarate. Mutations of the FAH gene are associated with hereditary tyrosinemia type...

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Dettagli Bibliografici
Pubblicato in:Int J Mol Sci
Autori principali: Kaushal, Kamini, Woo, Sang Hyeon, Tyagi, Apoorvi, Kim, Dong Ha, Suresh, Bharathi, Kim, Kye-Seong, Ramakrishna, Suresh
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7699203/
https://ncbi.nlm.nih.gov/pubmed/33218190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21228719
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