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Fine-tuning of lysine side chain modulates the activity of histone lysine methyltransferases
Histone lysine methyltransferases (KMTs) play an important role in epigenetic gene regulation and have emerged as promising targets for drug discovery. However, the scope and limitation of KMT catalysis on substrates possessing substituted lysine side chains remain insufficiently explored. Here, we...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7726145/ https://ncbi.nlm.nih.gov/pubmed/33299050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78331-0 |
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