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Fine-tuning of lysine side chain modulates the activity of histone lysine methyltransferases
Histone lysine methyltransferases (KMTs) play an important role in epigenetic gene regulation and have emerged as promising targets for drug discovery. However, the scope and limitation of KMT catalysis on substrates possessing substituted lysine side chains remain insufficiently explored. Here, we...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7726145/ https://ncbi.nlm.nih.gov/pubmed/33299050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78331-0 |
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