Fine-tuning of lysine side chain modulates the activity of histone lysine methyltransferases

Histone lysine methyltransferases (KMTs) play an important role in epigenetic gene regulation and have emerged as promising targets for drug discovery. However, the scope and limitation of KMT catalysis on substrates possessing substituted lysine side chains remain insufficiently explored. Here, we...

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Vydáno v:Sci Rep
Hlavní autoři: Al Temimi, Abbas H. K., Merx, Jona, van Noortwijk, Christian J., Proietti, Giordano, Buijs, Romano, White, Paul B., Rutjes, Floris P. J. T., Boltje, Thomas J., Mecinović, Jasmin
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7726145/
https://ncbi.nlm.nih.gov/pubmed/33299050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78331-0
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