Fine-tuning of lysine side chain modulates the activity of histone lysine methyltransferases

Histone lysine methyltransferases (KMTs) play an important role in epigenetic gene regulation and have emerged as promising targets for drug discovery. However, the scope and limitation of KMT catalysis on substrates possessing substituted lysine side chains remain insufficiently explored. Here, we...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Al Temimi, Abbas H. K., Merx, Jona, van Noortwijk, Christian J., Proietti, Giordano, Buijs, Romano, White, Paul B., Rutjes, Floris P. J. T., Boltje, Thomas J., Mecinović, Jasmin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7726145/
https://ncbi.nlm.nih.gov/pubmed/33299050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78331-0
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