Examining sterically demanding lysine analogs for histone lysine methyltransferase catalysis

Methylation of lysine residues in histone proteins is catalyzed by S-adenosylmethionine (SAM)-dependent histone lysine methyltransferases (KMTs), a genuinely important class of epigenetic enzymes of biomedical interest. Here we report synthetic, mass spectrometric, NMR spectroscopic and quantum mech...

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Publicado no:Sci Rep
Main Authors: Temimi, Abbas H. K. Al, Tran, Vu, Teeuwen, Ruben S., Altunc, Arthur J., Amatdjais-Groenen, Helene I. V., White, Paul B., Lenstra, Danny C., Proietti, Giordano, Wang, Yali, Wegert, Anita, Blaauw, Richard H., Qian, Ping, Ren, Wansheng, Guo, Hong, Mecinović, Jasmin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7048932/
https://ncbi.nlm.nih.gov/pubmed/32111884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60337-3
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