Context-Dependent Requirement of Euchromatic Histone Methyltransferase Activity during Reprogramming to Pluripotency

Methylation of histone 3 at lysine 9 (H3K9) constitutes a roadblock for cellular reprogramming. Interference with methyltransferases or activation of demethylases by the cofactor ascorbic acid (AA) facilitates the derivation of induced pluripotent stem cells (iPSCs), but possible interactions betwee...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Vidal, Simon E., Polyzos, Alexander, Chatterjee, Kaushiki, Ee, Ly-sha, Swanzey, Emily, Morales-Valencia, Jorge, Wang, Hongsu, Parikh, Chaitanya N., Amlani, Bhishma, Tu, Shengjiang, Gong, Yixiao, Snetkova, Valentina, Skok, Jane A., Tsirigos, Aristotelis, Kim, Sangyong, Apostolou, Effie, Stadtfeld, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7724475/
https://ncbi.nlm.nih.gov/pubmed/32976761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.08.011
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