H3K27ac bookmarking promotes rapid post-mitotic activation of the pluripotent stem cell program without impacting 3D chromatin reorganization

During self-renewal, cell type-defining features are drastically perturbed in mitosis and must be faithfully reestablished upon G1 entry; a process that remains largely elusive. Here, we characterized at a genome-wide scale the dynamic transcriptional and architectural resetting of mouse pluripotent...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell
Prif Awduron: Pelham-Webb, Bobbie, Polyzos, Alexander, Wojenski, Luke, Kloetgen, Andreas, Li, Jiexi, Di Giammartino, Dafne Campigli, Sakellaropoulos, Theodore, Tsirigos, Aristotelis, Core, Leighton, Apostolou, Effie
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8052294/
https://ncbi.nlm.nih.gov/pubmed/33730542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.02.032
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