Protection from α-Synuclein induced dopaminergic neurodegeneration by overexpression of the mitochondrial import receptor TOM20

Dopaminergic neurons of the substantia nigra are selectively vulnerable to mitochondrial dysfunction, which is hypothesized to be an early and fundamental pathogenic mechanism in Parkinson’s disease (PD). Mitochondrial function depends on the successful import of nuclear-encoded proteins, many of wh...

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Bibliografske podrobnosti
izdano v:NPJ Parkinsons Dis
Main Authors: De Miranda, Briana R., Rocha, Emily M., Castro, Sandra L., Greenamyre, J. Timothy
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7722884/
https://ncbi.nlm.nih.gov/pubmed/33293540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41531-020-00139-6
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