Distal and proximal hypoxia response elements co-operate to regulate organ-specific erythropoietin gene expression

While it has been well-established that distal hypoxia response elements (HRE) regulate hypoxia-inducible factor (HIF) target genes such as erythropoietin (Epo), an interplay between multiple distal and proximal (promoter) HRE has not yet been described. Hepatic Epo expression is regulated by an HRE...

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Vydáno v:Haematologica
Hlavní autoři: Orlando, Ilaria M. C., Lafleur, Véronique N., Storti, Federica, Spielmann, Patrick, Crowther, Lisa, Santambrogio, Sara, Schödel, Johannes, Hoogewijs, David, Mole, David R., Wenger, Roland H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Fondazione Ferrata Storti 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7716368/
https://ncbi.nlm.nih.gov/pubmed/33256376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.236406
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