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Distal and proximal hypoxia response elements co-operate to regulate organ-specific erythropoietin gene expression

While it has been well-established that distal hypoxia response elements (HRE) regulate hypoxia-inducible factor (HIF) target genes such as erythropoietin (Epo), an interplay between multiple distal and proximal (promoter) HRE has not yet been described. Hepatic Epo expression is regulated by an HRE...

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Bibliografische gegevens
Gepubliceerd in:Haematologica
Hoofdauteurs: Orlando, Ilaria M. C., Lafleur, Véronique N., Storti, Federica, Spielmann, Patrick, Crowther, Lisa, Santambrogio, Sara, Schödel, Johannes, Hoogewijs, David, Mole, David R., Wenger, Roland H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Fondazione Ferrata Storti 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7716368/
https://ncbi.nlm.nih.gov/pubmed/33256376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.236406
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