Distal and proximal hypoxia response elements co-operate to regulate organ-specific erythropoietin gene expression

While it has been well-established that distal hypoxia response elements (HRE) regulate hypoxia-inducible factor (HIF) target genes such as erythropoietin (Epo), an interplay between multiple distal and proximal (promoter) HRE has not yet been described. Hepatic Epo expression is regulated by an HRE...

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Detalhes bibliográficos
Publicado no:Haematologica
Main Authors: Orlando, Ilaria M. C., Lafleur, Véronique N., Storti, Federica, Spielmann, Patrick, Crowther, Lisa, Santambrogio, Sara, Schödel, Johannes, Hoogewijs, David, Mole, David R., Wenger, Roland H.
Formato: Artigo
Idioma:Inglês
Publicado em: Fondazione Ferrata Storti 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7716368/
https://ncbi.nlm.nih.gov/pubmed/33256376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.236406
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