Destruction of a distal hypoxia response element abolishes trans-activation of the PAG1 gene mediated by HIF-independent chromatin looping

A crucial step in the cellular adaptation to oxygen deficiency is the binding of hypoxia-inducible factors (HIFs) to hypoxia response elements (HREs) of oxygen-regulated genes. Genome-wide HIF-1α/2α/β DNA-binding studies revealed that the majority of HREs reside distant to the promoter regions, but...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Schörg, Alexandra, Santambrogio, Sara, Platt, James L., Schödel, Johannes, Lindenmeyer, Maja T., Cohen, Clemens D., Schrödter, Katrin, Mole, David R., Wenger, Roland H., Hoogewijs, David
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Gene regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499134/
https://ncbi.nlm.nih.gov/pubmed/26007655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv506
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