Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway

Un-physiological activation of hypoxia inducible factor (HIF) is an early event in most renal cell cancers (RCC) following inactivation of the von Hippel-Lindau tumor suppressor. Despite intense study, how this impinges on cancer development is incompletely understood. To test for the impact of gene...

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Vydáno v:PLoS Genet
Hlavní autoři: Grampp, Steffen, Schmid, Virginia, Salama, Rafik, Lauer, Victoria, Kranz, Franziska, Platt, James L., Smythies, James, Choudhry, Hani, Goppelt-Struebe, Margarete, Ratcliffe, Peter J., Mole, David R., Schödel, Johannes
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5536434/
https://ncbi.nlm.nih.gov/pubmed/28715484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006872
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