LGG-17. SYNERGISTIC ACTIVITY OF MAPK INHIBITOR CLASSES REVEALED BY A NOVEL CELL-BASED MAPK ACTIVITY PEDIATRIC LOW-GRADE GLIOMA ASSAY

Pilocytic astrocytomas (PAs) and other pediatric low-grade gliomas (pLGGs) exhibit aberrant activation of the MAPK signaling pathway caused by genetic alterations, most commonly KIAA1549:BRAF fusions, BRAF V600E and NF1 mutations. In such a single-pathway disease, novel drugs targeting the MAPK path...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Usta, Diren, Sigaud, Romain, Buhl, Juliane L, Selt, Florian, Marquardt, Viktoria, Pauck, David, Pusch, Stefan, Ecker, Jonas, Hielscher, Thomas, Vollmer, Johanna, Sommerkamp, Alexander C, Rubner, Tobias, Hargrave, Darren, van Tilburg, Cornelis M, Pfister, Stefan M, Jones, David T W, Remke, Marc, Brummer, Tilman, Witt, Olaf, Milde, Till
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Low Grade Glioma
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715150/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.399
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados