LGG-04. CHARACTERIZATION OF ONCOGENE-INDUCED SENESCENCE AND THE ROLE OF THE SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE IN PILOCYTIC ASTROCYTOMA

The benign but unpredictable growth behaviour of pilocytic astrocytoma (PA) is thought to originate from variations in proliferation caused by oncogene-induced senescence (OIS). An increase in MAPK pathway activation, present in virtually all PAs, serves a stimulus driving the tumor into OIS. Upregu...

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Publicado no:Neuro Oncol
Main Authors: Hohloch, Juliane, Selt, Florian, Hielscher, Thomas, Sahm, Felix, Capper, David, Usta, Diren, Ecker, Jonas, Oehme, Ina, van Tilburg, Cornelis M., von Deimling, Andreas, Schuhmann, Martin U., Korshunov, Andrey, Jones, David T.W., Brummer, Tilman, Pfister, Stefan M., Witt, Olaf, Milde, Till
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475128/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.137
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