PDTM-47. CHARACTERIZATION OF THE SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE IN PILOCYTIC ASTROCYTOMA AND ITS ROLE IN ONCOGENE-INDUCED SENESCENCE

Pilocytic astrocytoma (PA) is the most frequent pediatric brain tumor. This single-pathway disease exhibits aberrant activation of the MAPK pathway driving the tumor into oncogene-induced senescence (OIS). OIS is proposed to be the source of the unstable however benign growth observed in PA patients...

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Publié dans:Neuro Oncol
Auteurs principaux: Hohloch, Juliane, Selt, Florian, Hielscher, Thomas, Sahm, Felix, Capper, David, Usta, Diren, Ecker, Jonas, Oehme, Ina, van Tilburg, Cornelis M, von Deimling, Andreas, Schuhmann, Martin U, Korshunov, Andrey, Jones, David, Brummer, Tilman, Pfister, Stefan M, Witt, Olaf, Milde, Till
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692619/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.809
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