LGG-11. BH3-MIMETICS TARGETING BCL-XL SELECTIVELY IMPACT THE SENESCENT COMPARTMENT OF PILOCYTIC ASTROCYTOMA

INTRODUCTION: Pilocytic astrocytoma (PA) is the most common brain tumor in children. Activation of the mitogen-activated protein kinase (MAPK) pathway is a hallmark of PA. Complete remission in non-resectable tumors is infrequently observed with current therapeutic approaches. Most PA tumors cells a...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Selt, Florian, Sigaud, Romain, Sievers, Philipp, Zaman, Julia, Peterziel, Heike, Tsai, Jessica W, Guiho, Romain, Martínez-Barbera, Juan Pedro, Pusch, Stefan, Schuhmann, Martin U, El Damaty, Ahmed, Bandopadhayay, Pratiti, Pfister, Stefan M, Oehme, Ina, Sahm, Felix, Jones, David T W, Witt, Olaf, Milde, Till
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2021
Soggetti:
Low Grade Gliomas
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168081/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.135
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