LGG-17. SYNERGISTIC ACTIVITY OF MAPK INHIBITOR CLASSES REVEALED BY A NOVEL CELL-BASED MAPK ACTIVITY PEDIATRIC LOW-GRADE GLIOMA ASSAY

Pilocytic astrocytomas (PAs) and other pediatric low-grade gliomas (pLGGs) exhibit aberrant activation of the MAPK signaling pathway caused by genetic alterations, most commonly KIAA1549:BRAF fusions, BRAF V600E and NF1 mutations. In such a single-pathway disease, novel drugs targeting the MAPK path...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neuro Oncol
Prif Awduron: Usta, Diren, Sigaud, Romain, Buhl, Juliane L, Selt, Florian, Marquardt, Viktoria, Pauck, David, Pusch, Stefan, Ecker, Jonas, Hielscher, Thomas, Vollmer, Johanna, Sommerkamp, Alexander C, Rubner, Tobias, Hargrave, Darren, van Tilburg, Cornelis M, Pfister, Stefan M, Jones, David T W, Remke, Marc, Brummer, Tilman, Witt, Olaf, Milde, Till
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2020
Pynciau:
Low Grade Glioma
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715150/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.399
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