LGG-17. SYNERGISTIC ACTIVITY OF MAPK INHIBITOR CLASSES REVEALED BY A NOVEL CELL-BASED MAPK ACTIVITY PEDIATRIC LOW-GRADE GLIOMA ASSAY

Pilocytic astrocytomas (PAs) and other pediatric low-grade gliomas (pLGGs) exhibit aberrant activation of the MAPK signaling pathway caused by genetic alterations, most commonly KIAA1549:BRAF fusions, BRAF V600E and NF1 mutations. In such a single-pathway disease, novel drugs targeting the MAPK path...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Usta, Diren, Sigaud, Romain, Buhl, Juliane L, Selt, Florian, Marquardt, Viktoria, Pauck, David, Pusch, Stefan, Ecker, Jonas, Hielscher, Thomas, Vollmer, Johanna, Sommerkamp, Alexander C, Rubner, Tobias, Hargrave, Darren, van Tilburg, Cornelis M, Pfister, Stefan M, Jones, David T W, Remke, Marc, Brummer, Tilman, Witt, Olaf, Milde, Till
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Low Grade Glioma
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715150/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.399
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker