A role for LSH in facilitating DNA methylation by DNMT1 through enhancing UHRF1 chromatin association

LSH, a SNF2 family DNA helicase, is a key regulator of DNA methylation in mammals. How LSH facilitates DNA methylation is not well defined. While previous studies with mouse embryonic stem cells (mESc) and fibroblasts (MEFs) derived from Lsh knockout mice have revealed a role of Lsh in de novo DNA m...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Han, Mengmeng, Li, Jialun, Cao, Yaqiang, Huang, Yuanyong, Li, Wen, Zhu, Haijun, Zhao, Qian, Han, Jing-Dong Jackie, Wu, Qihan, Li, Jiwen, Feng, Jing, Wong, Jiemin
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708066/
https://ncbi.nlm.nih.gov/pubmed/33170271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1003
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