A role for LSH in facilitating DNA methylation by DNMT1 through enhancing UHRF1 chromatin association

LSH, a SNF2 family DNA helicase, is a key regulator of DNA methylation in mammals. How LSH facilitates DNA methylation is not well defined. While previous studies with mouse embryonic stem cells (mESc) and fibroblasts (MEFs) derived from Lsh knockout mice have revealed a role of Lsh in de novo DNA m...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Han, Mengmeng, Li, Jialun, Cao, Yaqiang, Huang, Yuanyong, Li, Wen, Zhu, Haijun, Zhao, Qian, Han, Jing-Dong Jackie, Wu, Qihan, Li, Jiwen, Feng, Jing, Wong, Jiemin
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Gene regulation, Chromatin and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708066/
https://ncbi.nlm.nih.gov/pubmed/33170271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1003
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