Negative regulation of DNMT3A de novo DNA methylation by frequently overexpressed UHRF family proteins as a mechanism for widespread DNA hypomethylation in cancer

Global DNA hypomethylation is a most common epigenetic alteration in cancer, but the mechanism remains elusive. Previous studies demonstrate that UHRF1 but not UHRF2 is required for mediating DNA maintenance methylation by DNMT1. Here we report unexpectedly a conserved function for UHRF1 and UHRF2:...

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Publicado no:Cell Discov
Main Authors: Jia, Yuanhui, Li, Pishun, Fang, Lan, Zhu, Haijun, Xu, Liangliang, Cheng, Hao, Zhang, Junying, Li, Fei, Feng, Yan, Li, Yan, Li, Jialun, Wang, Ruiping, Du, James X, Li, Jiwen, Chen, Taiping, Ji, Hongbin, Han, Jackie, Yu, Wenqiang, Wu, Qihan, Wong, Jiemin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849474/
https://ncbi.nlm.nih.gov/pubmed/27462454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.7
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