Structural distinctions between NAD(+) riboswitch domains 1 and 2 determine differential folding and ligand binding

Riboswitches are important gene regulatory elements frequently encountered in bacterial mRNAs. The recently discovered nadA riboswitch contains two similar, tandemly arrayed aptamer domains, with the first domain possessing high affinity for nicotinamide adenine dinucleotide (NAD(+)). The second dom...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Chen, Hao, Egger, Michaela, Xu, Xiaochen, Flemmich, Laurin, Krasheninina, Olga, Sun, Aiai, Micura, Ronald, Ren, Aiming
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Structural Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708056/
https://ncbi.nlm.nih.gov/pubmed/33170270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1029
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