Structural distinctions between NAD(+) riboswitch domains 1 and 2 determine differential folding and ligand binding

Riboswitches are important gene regulatory elements frequently encountered in bacterial mRNAs. The recently discovered nadA riboswitch contains two similar, tandemly arrayed aptamer domains, with the first domain possessing high affinity for nicotinamide adenine dinucleotide (NAD(+)). The second dom...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Chen, Hao, Egger, Michaela, Xu, Xiaochen, Flemmich, Laurin, Krasheninina, Olga, Sun, Aiai, Micura, Ronald, Ren, Aiming
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2020
Pynciau:
Structural Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708056/
https://ncbi.nlm.nih.gov/pubmed/33170270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1029
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