Structural distinctions between NAD(+) riboswitch domains 1 and 2 determine differential folding and ligand binding

Riboswitches are important gene regulatory elements frequently encountered in bacterial mRNAs. The recently discovered nadA riboswitch contains two similar, tandemly arrayed aptamer domains, with the first domain possessing high affinity for nicotinamide adenine dinucleotide (NAD(+)). The second dom...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Chen, Hao, Egger, Michaela, Xu, Xiaochen, Flemmich, Laurin, Krasheninina, Olga, Sun, Aiai, Micura, Ronald, Ren, Aiming
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
Assuntos:
Structural Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708056/
https://ncbi.nlm.nih.gov/pubmed/33170270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1029
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