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Discovery of small-molecule inhibitors of multidrug-resistance plasmid maintenance using a high-throughput screening approach
Carbapenem-resistant Enterobacteriaceae (CRE) are multidrug-resistant pathogens for which new treatments are desperately needed. Carbapenemases and other types of antibiotic resistance genes are carried almost exclusively on large, low-copy-number plasmids (pCRE). Accordingly, small molecules that e...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7703651/ https://ncbi.nlm.nih.gov/pubmed/33168749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005948117 |
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