Discovery of Small Molecule Inhibitors of Human Uridine-Cytidine Kinase 2 by High-Throughput Screening

Clinically relevant inhibitors of dihydroorotate dehydrogenase (DHODH), a rate-limiting enzyme in mammalian de novo pyrimidine synthesis, have strong antiviral and anticancer activity in vitro. However, they are ineffective in vivo due to efficient uridine salvage by infected or rapidly dividing cel...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Bioorg Med Chem Lett
Main Authors: Okesli-Armlovich, Ayse, Gupta, Amita, Jimenez, Marta, Auld, Douglas, Liu, Qi, Bassik, Michael C., Khosla, Chaitan
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719797/
https://ncbi.nlm.nih.gov/pubmed/31420268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.08.010
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