Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism

Genome-wide analysis of the mode of action of GSK983, a potent antiviral agent, led to the identification of dihydroorotate dehydrogenase as its target along with the discovery that genetic knockdown of pyrimidine salvage sensitized cells to GSK983. Because GSK983 is an ineffective antiviral in the...

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Publicado no:Cell Chem Biol
Main Authors: Liu, Qi, Gupta, Amita, Okesli-Armlovich, Ayse, Qiao, Wenjie, Fischer, Curt R., Smith, Mark, Carette, Jan E., Bassik, Michael C., Khosla, Chaitan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7241336/
https://ncbi.nlm.nih.gov/pubmed/32442424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.05.002
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