Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism

Genome-wide analysis of the mode of action of GSK983, a potent antiviral agent, led to the identification of dihydroorotate dehydrogenase as its target along with the discovery that genetic knockdown of pyrimidine salvage sensitized cells to GSK983. Because GSK983 is an ineffective antiviral in the...

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Dettagli Bibliografici
Pubblicato in:Cell Chem Biol
Autori principali: Liu, Qi, Gupta, Amita, Okesli-Armlovich, Ayse, Qiao, Wenjie, Fischer, Curt R., Smith, Mark, Carette, Jan E., Bassik, Michael C., Khosla, Chaitan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier Ltd. 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7241336/
https://ncbi.nlm.nih.gov/pubmed/32442424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.05.002
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