Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

Broad spectrum antiviral drugs targeting host processes could potentially treat a wide range of viruses while reducing the likelihood of emergent resistance. Despite great promise as therapeutics, such drugs remain largely elusive. Here we use parallel genome-wide high-coverage shRNA and CRISPR-Cas9...

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Publicat a:Nat Chem Biol
Autors principals: Deans, Richard M., Morgens, David W., Ökesli, Ayşe, Pillay, Sirika, Horlbeck, Max A., Kampmann, Martin, Gilbert, Luke A., Li, Amy, Mateo, Roberto, Smith, Mark, Glenn, Jeffrey S., Carette, Jan E., Khosla, Chaitan, Bassik, Michael C.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836973/
https://ncbi.nlm.nih.gov/pubmed/27018887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2050
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