Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

Broad spectrum antiviral drugs targeting host processes could potentially treat a wide range of viruses while reducing the likelihood of emergent resistance. Despite great promise as therapeutics, such drugs remain largely elusive. Here we use parallel genome-wide high-coverage shRNA and CRISPR-Cas9...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Deans, Richard M., Morgens, David W., Ökesli, Ayşe, Pillay, Sirika, Horlbeck, Max A., Kampmann, Martin, Gilbert, Luke A., Li, Amy, Mateo, Roberto, Smith, Mark, Glenn, Jeffrey S., Carette, Jan E., Khosla, Chaitan, Bassik, Michael C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836973/
https://ncbi.nlm.nih.gov/pubmed/27018887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2050
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