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Systematic comparison of CRISPR-Cas9 and RNAi screens for essential genes
We compare the ability of shRNA and CRISPR/Cas9 screens to identify essential genes in the human chronic myelogenous leukemia cell line K562. We find that the precision of the two libraries in detecting essential genes is similar and that combining data from both screens improves performance. Notabl...
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| Publicado no: | Nat Biotechnol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4900911/ https://ncbi.nlm.nih.gov/pubmed/27159373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3567 |
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