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CRISPR-Cas9 screens identify regulators of antibody-drug conjugate toxicity
Antibody-drug conjugates (ADCs) selectively deliver chemotherapeutic agents to target cells and are important cancer therapeutics. However, the mechanisms by which ADCs are internalized and activated remain unclear. Using CRISPR-Cas9 screens, we uncover many known and novel endolysosomal regulators...
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| Publicado no: | Nat Chem Biol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6911768/ https://ncbi.nlm.nih.gov/pubmed/31451760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0342-2 |
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