CRISPR-Cas9 screens identify regulators of antibody-drug conjugate toxicity

Antibody-drug conjugates (ADCs) selectively deliver chemotherapeutic agents to target cells and are important cancer therapeutics. However, the mechanisms by which ADCs are internalized and activated remain unclear. Using CRISPR-Cas9 screens, we uncover many known and novel endolysosomal regulators...

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Udgivet i:Nat Chem Biol
Main Authors: Tsui, C. Kimberly, Barfield, Robyn M., Fischer, Curt R., Morgens, David W., Li, Amy, Smith, Benjamin A. H., Gray, Melissa Anne, Bertozzi, Carolyn R., Rabuka, David, Bassik, Michael C.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911768/
https://ncbi.nlm.nih.gov/pubmed/31451760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0342-2
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