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Systematic comparison of CRISPR-Cas9 and RNAi screens for essential genes
We compare the ability of shRNA and CRISPR/Cas9 screens to identify essential genes in the human chronic myelogenous leukemia cell line K562. We find that the precision of the two libraries in detecting essential genes is similar and that combining data from both screens improves performance. Notabl...
שמור ב:
| הוצא לאור ב: | Nat Biotechnol |
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| Main Authors: | , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2016
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4900911/ https://ncbi.nlm.nih.gov/pubmed/27159373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3567 |
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