Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

Broad spectrum antiviral drugs targeting host processes could potentially treat a wide range of viruses while reducing the likelihood of emergent resistance. Despite great promise as therapeutics, such drugs remain largely elusive. Here we use parallel genome-wide high-coverage shRNA and CRISPR-Cas9...

詳細記述

保存先:
書誌詳細
出版年:Nat Chem Biol
主要な著者: Deans, Richard M., Morgens, David W., Ökesli, Ayşe, Pillay, Sirika, Horlbeck, Max A., Kampmann, Martin, Gilbert, Luke A., Li, Amy, Mateo, Roberto, Smith, Mark, Glenn, Jeffrey S., Carette, Jan E., Khosla, Chaitan, Bassik, Michael C.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836973/
https://ncbi.nlm.nih.gov/pubmed/27018887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2050
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