Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism

Genome-wide analysis of the mode of action of GSK983, a potent antiviral agent, led to the identification of dihydroorotate dehydrogenase as its target along with the discovery that genetic knockdown of pyrimidine salvage sensitized cells to GSK983. Because GSK983 is an ineffective antiviral in the...

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Détails bibliographiques
Publié dans:Cell Chem Biol
Auteurs principaux: Liu, Qi, Gupta, Amita, Okesli-Armlovich, Ayse, Qiao, Wenjie, Fischer, Curt R., Smith, Mark, Carette, Jan E., Bassik, Michael C., Khosla, Chaitan
Format: Artigo
Langue:Inglês
Publié: Elsevier Ltd. 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7241336/
https://ncbi.nlm.nih.gov/pubmed/32442424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.05.002
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