Discovery of Small Molecule Inhibitors of Human Uridine-Cytidine Kinase 2 by High-Throughput Screening

Clinically relevant inhibitors of dihydroorotate dehydrogenase (DHODH), a rate-limiting enzyme in mammalian de novo pyrimidine synthesis, have strong antiviral and anticancer activity in vitro. However, they are ineffective in vivo due to efficient uridine salvage by infected or rapidly dividing cel...

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Veröffentlicht in:Bioorg Med Chem Lett
Hauptverfasser: Okesli-Armlovich, Ayse, Gupta, Amita, Jimenez, Marta, Auld, Douglas, Liu, Qi, Bassik, Michael C., Khosla, Chaitan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719797/
https://ncbi.nlm.nih.gov/pubmed/31420268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.08.010
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