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Discovery of small molecule inhibitors for the C. elegans caspase CED-3 by high-throughput screening
C. elegans has been widely used as a model organism for programmed cell death and apoptosis. Although the CED-3 caspase is the primary effector of cell death in C. elegans, no selective inhibitors have been identified. Utilizing high-throughput screening with recombinant C. elegans CED-3 protein, we...
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| Publicat a: | Biochem Biophys Res Commun |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5590106/ https://ncbi.nlm.nih.gov/pubmed/28733033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2017.07.100 |
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