Discovery of small molecule inhibitors for the C. elegans caspase CED-3 by high-throughput screening

C. elegans has been widely used as a model organism for programmed cell death and apoptosis. Although the CED-3 caspase is the primary effector of cell death in C. elegans, no selective inhibitors have been identified. Utilizing high-throughput screening with recombinant C. elegans CED-3 protein, we...

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Detalhes bibliográficos
Publicado no:Biochem Biophys Res Commun
Main Authors: Brantley, Scott J., Cotten, Steven W., Lamson, David R., Smith, Ginger R., Liu, Rihe, Williams, Kevin P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590106/
https://ncbi.nlm.nih.gov/pubmed/28733033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2017.07.100
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