High-throughput small molecule screen identifies inhibitors of aberrant chromatin accessibility

Mutations in chromatin-modifying proteins and transcription factors are commonly associated with a wide variety of cancers. Through gain- or loss-of-function, these mutations may result in characteristic alterations of accessible chromatin, indicative of shifts in the landscape of regulatory element...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Pattenden, Samantha G., Simon, Jeremy M., Wali, Aminah, Jayakody, Chatura N., Troutman, Jacob, McFadden, Andrew W., Wooten, Joshua, Wood, Cameron C., Frye, Stephen V., Janzen, William P., Davis, Ian J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801272/
https://ncbi.nlm.nih.gov/pubmed/26929321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521827113
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