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High-throughput sequencing of the transcriptome and chromatin accessibility in the same cell

Single-cell RNA sequencing can reveal the transcriptional state of cells, yet provides little insight into the upstream regulatory landscape associated with open or accessible chromatin regions. Joint profiling of accessible chromatin and RNA within the same cells would permit direct matching of tra...

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Detalles Bibliográficos
Publicado en:Nat Biotechnol
Autores principales: Chen, Song, Lake, Blue B, Zhang, Kun
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6893138/
https://ncbi.nlm.nih.gov/pubmed/31611697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-019-0290-0
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